NFκB 信號靶標PCR 芯片 NFκB Signaling Targets PCR Array
NFκB 信號靶標PCR 芯片 NFκB Signaling Targets PCR Array
NFκB 信號靶標PCR 芯片 NFκB Signaling Targets PCR Array
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| 地區(qū)： | 上海 |
| 簡介： | 上海 |
| 提供商： | SABio |
| 服務名稱： | PCR芯片 |
NFκB 信號靶標PCR 芯片可用于研究84個NFκB信號轉(zhuǎn)導應答關鍵基因的表達。NFκB家族的轉(zhuǎn)錄因子，可調(diào)節(jié)多種細胞過程，包括炎癥，免疫和應激反應。IκB抑制劑家族使這些轉(zhuǎn)錄因子隔絕在細胞質(zhì)中。多種配體如各種炎癥細胞因子，生長因子及來自病原體的抗原可以激活的NFκB信號通路導致IκB蛋白的磷酸化和去磷酸化。新釋放的NFκB轉(zhuǎn)錄因子形成有活性的復合物進入細胞核，誘導其靶基因的表達。炎癥或自身免疫性疾病可以導致該信號轉(zhuǎn)導通路的失調(diào)。通過各種實驗技術如表達譜分析、ChIP和轉(zhuǎn)錄因子結合位點的生物信息學預測，鑒定得出了大量的NFκB靶標基因。該芯片涵蓋了NFκB轉(zhuǎn)錄因子和多種實驗驗證得到的高度相關性靶標基因，芯片結果可用來分析NFκB信號傳導的激活或抑制。通過實時定量PCR的方法，研究者即能夠利用該芯片簡單可靠地同時檢測NFκB關聯(lián)細胞活動相關基因的表達。
Cytokines & Chemokines: CCL11, CCL2 (MCP-1), CCL22 (MDC), CCL5 (RANTES), CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (GCSF), CXCL1, CXCL10 (INP10), CXCL2, CXCL9 (MIG), FASLG (TNFSF6), IFNB1, IFNG, IL12B, IL15, IL1A, IL1B, IL1RN, IL2, IL4, IL6, IL8, LTA (TNFB), LTB, TNF, TNFSF10 (TRAIL). Inflammation: Acute: C3, CCL5 (RANTES), CFB (BF), F3, F8, IL1A, IL1B, IL6, INS, STAT3, STAT5B. Other Inflammatory Genes: AGT, AKT1, CCL11, CCL2 (MCP-1), CCL22 (MDC), CCR5, CD40 (TNFRSF5), CXCL1, CXCL10 (INP10), CXCL2, CXCL9 (MIG), IL15, IL1RN, IL2, IL2RA (CD25), IL8, MYD88, PTGS2 (COX-2), SELE, SELP, TNF, TNFRSF1B. Apoptosis: AGT, BIRC2 (c-IAP2), EGFR, FASLG (TNFSF6), GADD45B, IFNB1, IFNG, IL12B, IL2RA (CD25), IL4, INS, LTA (TNFB), MAP2K6 (MEK6), MMP9 (Gelatinase B), NQO1, NR4A2 (NUR77), PTGS2 (COX-2), STAT1, TNFRSF1B, TNFSF10 (TRAIL), TP53, TRAF2. Anti-Apoptosis: ADM, AKT1, BCL2A1 (BFL-1/A1), BCL2L1 (BCL-X), BIRC3 (c-IAP1), CCL2 (MCP-1), CDKN1A (p21CIP1/WAF1), CSF2 (GM-CSF), F3, FAS (TNFRSF6), IL1A, IL1B, IL2, IL6, MYD88, NFKBIA (IkBa/MAD3), SOD2, STAT5B, TNF, XIAP. Immune Response: Innate: C3, CCL2 (MCP-1), CFB (BF), IFNB1, IL12B, IL6, INS, MYD88, NFKBIA (IkBa/MAD3), STAT5B, TNF. Adaptive: C3, CCL2 (MCP-1), CD40 (TNFRSF5), CD80, ICAM1, IFNG, IL12B, IL1B, IL2, IL4, TRAF2. Other Immunity-Related Genes: CD83, FAS (TNFRSF6), FASLG (TNFSF6), IL1R2, IL8, LTA (TNFB), LTB, TNFSF10 (TRAIL). Type I Interferon-Responsive Genes: ADM, CCL2 (MCP-1), CCL5 (RANTES), CD69, CD80, CDKN1A (p21CIP1/WAF1), CFB (BF), CXCL10 (INP10), CXCL9 (MIG), IL15, IL1RN, IRF1, MYD88, NCOA3, STAT1, TNFSF10 (TRAIL). Development & Differentiation: Lymphoid: CD80, CD83, IL12B, IL15, IL2, IL2RA (CD25), IL4, IRF1, STAT5B, TP53, VCAM1. Myeloid: CCL5 (RANTES), CSF1 (MCSF), CSF2 (GM-CSF), CSF2RB, CSF3 (GCSF), IL4, MMP9 (Gelatinase B), NFKBIA (IkBa/MAD3), STAT5B, TNF. Nervous System: AGT, ALDH3A2, CXCL1, EGFR, EGR2, IFNG, NR4A2 (NUR77), SNAP25, SOD2, STAT3, TP53. Stress Response: ADM, AKT1, BCL2L1 (BCL-X), BIRC2 (c-IAP2), CCND1, CDKN1A (p21CIP1/WAF1), GADD45B, IFNG, IL1A, IL1B, MAP2K6 (MEK6), NQO1, PDGFB, PLAU (uPA), SOD2, TNF, TP53, XIAP. NFkB Pathway: Signal Transduction: NFKB1, NFKB2, NFKBIA (IkBa/MAD3), RELB, STAT1. Regulation: BIRC2 (c-IAP2), CD40 (TNFRSF5), FASLG (TNFSF6), IL1B, MYD88, REL, RELA, TNF, TNFSF10 (TRAIL). Transcription Factors: NFkB Signaling: NFKB1, NFKB2, REL, RELA, RELB. Others: EGR2, IRF1, MYC, NR4A2 (NUR77), STAT1, STAT3, STAT5B, TP53. |
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